Study to Evaluate the Safety and Efficacy of MEM 3454 as Adjunctive Treatment in Combination With a Preexisting Antipsychotic in Patients With Cognitive Impairment Associated With Schizophrenia

Status unconfirmed · Phase 2 · Has a placebo group

Conditions studied: Cognitive Impairment Associated With Schizophrenia

In brief

To establish the proof of concept that MEM 3454, used as add-on pharmacotherapy, is a safe and effective treatment in patients with cognitive impairment associated with schizophrenia (CIAS).

Key facts

Study ID

NCT00604760

Run by

Memory Pharmaceuticals

People needed

160

Starts

2007-12-01

Last updated by the study team

2008-12-08

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of schizophrenia (any subtype), assessed using a structured interview.
• At least one month on the same dose of antipsychotic medication.
• Clinically stable, as judged by the investigator, and in a non-acute phase for at least 12 weeks.
• Able to provide informed consent.
• Fluent in English.
• Smokers and non-smokers.

You may not qualify if…

• First 3 years of schizophrenia diagnosis.
• Current risk of suicide, or history of suicidal behavior within the last 6 months.
• Hospitalized for psychiatric symptoms in the past 3 months.
• Other psychiatric diagnoses.
• Substance abuse/dependence (other than nicotine or caffeine) within the last 6 months according.
• Nicotine replacement therapy, smoking cessation medications or remedies, including Varenicline (Chantix).

Where it is running

• Telecare-Cresta Loma — Lemon Grove, California, United States
• Newport Bay Hospital — Newport Beach, California, United States
• Excell Research — Oceanside, California, United States
• Pasadena Research Institute — Pasadena, California, United States
• BHC Alhambra Hospital — Rosemead, California, United States
• California Clinical Trials Medical Group — San Diego, California, United States
• Neuropsychiatric Research Center of Orange County — Santa Ana, California, United States
• Coastal Communities Hospital — Santa Ana, California, United States
• Collaborative NeuroScience Network, Inc. — Torrance, California, United States
• Aventura Hospital — Aventura, Florida, United States
• Fort Lauderdale Hospital — Fort Lauderdale, Florida, United States
• Aventura Hospital — Miami, Florida, United States
• TuKoi Clinical Research — Miami, Florida, United States
• Professional Clinical Research, Inc. c/o Segal Institute for Clinical Research — North Miami, Florida, United States
• Scientific Clinical Research, Inc. — North Miami, Florida, United States
• Atlanta Center for Medical Research — Atlanta, Georgia, United States
• Berwyn Rehabilitation Center — Berwyn, Illinois, United States
• Alexian Brothers Behavioral Health Hospital — Hoffman Estates, Illinois, United States
• Alexian Brothers Center for Psychiatric Research — Hoffman Estates, Illinois, United States
• Chinmay K. Patel, DO — Hoffman Estates, Illinois, United States
• American Medical Research, Inc. — Oak Brook, Illinois, United States
• Clinical Research Institute — Wichita, Kansas, United States
• Parkwood Behavioral Health System — Olive Branch, Mississippi, United States
• St. Louis Clinical Trials, LC — St Louis, Missouri, United States
• CRI Worldwide, LLC at Lourdes Medical Center of Burlington County — Willingboro, New Jersey, United States

Full record on ClinicalTrials.gov

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