Role of Nitric Oxide in the Impact of Aging on Myocardial Remodeling

Completed · Not applicable

Conditions studied: Cardiovascular Diseases

In brief

The purpose of this study is to determine, with Positron Emission Tomography (PET), the role of nitric oxide in the age-associated effect on fatty acid and glucose delivery on myocardial substrate metabolism.

Key facts

Study ID

NCT00603720

Run by

Washington University School of Medicine

People needed

54

Starts

2005-09-01

Expected to finish

2008-06-01

Last updated by the study team

2018-09-12

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Between the ages of 18-35 or 60-75
• Normal glucose tolerance test
• Normal plasma fasting lipid panel (fasting total cholesterol less than 220 mg/dL)
• Normal rest/stress echocardiogram
• BMI (Body Mass Index) less than 30 kg/m2

You may not qualify if…

• Coronary artery disease
• High blood pressure
• Current smoker
• Diabetes mellitus
• Cardiovascular disease (signs and symptoms of any kind)
• History of stroke, peripheral vascular disease, or arrhythmia
• Pregnant or breastfeeding

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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