Mechanisms of Acute Asthma Exacerbations Through Molecular Analysis of Airway Secretions and Tissues

Completed

Conditions studied: Asthma

In brief

The purpose of this study is to investigate mechanisms which cause acute asthma exacerbations by examining blood and airway secretions during an acute onset (sputum or tracheal aspirates). This pilot study is intended to uncover new mechanisms of asthma exacerbation and to generate hypotheses for future study. By collaborating with Genentech, we (scientists at UCSF) plan to incorporate the latest scientific findings into our work to discover and develop new treatments for asthma.

Key facts

Study ID

NCT00603629

Run by

University of California, San Francisco

People needed

23

Starts

2008-01-01

Expected to finish

2009-09-01

Last updated by the study team

2026-05-01

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male and female subjects aged 18 - 70 years
• Medical history of asthma
• Currently experiencing an acute exacerbation of asthma
• Ability to provide informed consent or have a surrogate provide consent.
• Ability to provide sputum.

You may not qualify if…

• Cigarette smoking: Subjects must be non-smokers. Non-smokers are defined as subjects who have never smoked or who have not smoked for 1 year and have a total pack-year smoking history < 10 packs.
• Pregnant women.

Where it is running

• UCSF Airway Clinical Research Center — San Francisco, California, United States

Full record on ClinicalTrials.gov

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