Controlled Clinical Trial of Supplemental Oxygen for the Prevention of Post-Cesarean Infectious Morbidity

Completed · Not applicable

Conditions studied: Infection; Cesarean Section, Surgical Wound Infection, Endometritis

In brief

Previous studies have demonstrated that patients who undergo surgery while they under general anesthesia have fewer wound infections if they receive higher concentrations of oxygen but this has never been studied in women who are undergoing cesarean section. We plan to randomize women who are undergoing cesarean to receive either standard of care oxygen flow through a nasal cannula during their cesarean section only or a higher concentration of oxygen than they would typically receive through a face mask. Women will receive this therapy during their cesarean and for 2 hours afterwards. We will follow them after their surgery for evidence of infection either in their wound or their uterus.

Key facts

Study ID

NCT00603603

Run by

Washington University School of Medicine

People needed

606

Starts

2008-02-01

Expected to finish

2010-05-01

Last updated by the study team

2016-06-22

Who can join

Age: 12 and older, up to 50. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Pregnant patients undergoing a scheduled or unscheduled cesarean section with regional anesthesia

You may not qualify if…

• Urgent fetal or maternal indications for cesarean section precluding informed consent
• Evidence of extrauterine infection
• HIV infection
• Chronic steroid or other immunosuppressant use
• Patients undergoing general anesthesia

Where it is running

• Barnes Jewish Hospital/Washington University School. of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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