Effects of Varenicline on Brain Activity During Nicotine Abstinence

Completed · Not applicable · Has a placebo group

Conditions studied: Nicotine Dependence

In brief

This project aims to define mechanisms through which varenicline might be an effective smoking cessation medication.

Key facts

Study ID

NCT00602927

Run by

University of Pennsylvania

People needed

38

Starts

2007-11-01

Expected to finish

2008-08-01

Last updated by the study team

2011-05-10

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Treatment-seeking smokers between the ages of 18 and 65, that smoke at least 10 cigarettes/day for at least the past 6 months
• Provide a baseline CO (carbon monoxide) reading of >10ppm
• Provide written informed consent and are fluent, English-speaking
• Weight of equal to or less than 300 lbs

You may not qualify if…

• Smoking Behavior
• Use of chewing tobacco, snuff or cigars
• Current enrollment or plans to enroll in another smoking cessation program in the next 5 months
• Plan to use other nicotine substitutes or smoking cessation treatments in the next 5 months
• Provide a baseline CO (carbon monoxide) reading ≤10 ppm
• Alcohol/Drug Exclusion Criteria
• History of substance abuse and/or currently receiving treatment for substance abuse
• Current alcohol consumption that exceeds 25 standard drinks/week
• A breath alcohol concentration reading ≥ 0.01 at the H\&P (health \& physical) screening or either of the lab sessions
• Medication Exclusion Criteria
• Prior use of Chantix
• Current use or recent discontinuation (within last 14-days) of the following medications:
• Any form of smoking cessation medication
• Any form of anti-psychotic medications that includes:
• antipsychotics,
• atypical antipsychotics,
• mood-stabilizers,
• anti-depressants (tricyclic, SSRI, MAOI),
• anti-panic agents,
• anti-obsessive agents,
• anti-anxiety agents, and
• stimulants (e.g., Provigil, Ritalin)
• herbal medications (St. John's Wort)
• Opioid medication for chronic pain
• Anti-coagulants

Where it is running

• Tobacco Use Research Center — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.