Panitumumab, Chemotherapy, and External-Beam Radiation Therapy in Treating Patients With Locally Advanced Pancreatic Cancer That Cannot be Removed by Surgery
Completed · Phase 2
Conditions studied: Pancreatic Cancer
In brief
RATIONALE: Monoclonal antibodies, such as panitumumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Drugs used in chemotherapy, such as fluorouracil, capecitabine, and gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. External-beam radiation therapy uses high-energy x-rays to kill tumor cells. Panitumumab may also stop the growth of pancreatic cancer by blocking blood flow to the tumor and make tumor cells more sensitive to radiation therapy. Giving panitumumab together with chemotherapy and radiation therapy may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving panitumumab together with chemotherapy and external-beam radiation therapy works in treating patients with locally advanced pancreatic cancer that cannot be removed by surgery.
Key facts
- Study ID
- NCT00601627
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 52
- Starts
- 2009-06-01
- Expected to finish
- 2013-05-01
- Last updated by the study team
- 2017-04-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Boulder Community Hospital — Boulder, Colorado, United States
- Penrose Cancer Center at Penrose Hospital — Colorado Springs, Colorado, United States
- St. Anthony Central Hospital — Denver, Colorado, United States
- Porter Adventist Hospital — Denver, Colorado, United States
- Presbyterian - St. Luke's Medical Center — Denver, Colorado, United States
- St. Joseph Hospital — Denver, Colorado, United States
- Rose Medical Center — Denver, Colorado, United States
- CCOP - Colorado Cancer Research Program — Denver, Colorado, United States
- Swedish Medical Center — Englewood, Colorado, United States
- Front Range Cancer Specialists — Fort Collins, Colorado, United States
- St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center — Grand Junction, Colorado, United States
- North Colorado Medical Center — Greeley, Colorado, United States
- Sky Ridge Medical Center — Lone Tree, Colorado, United States
- Hope Cancer Care Center at Longmont United Hospital — Longmont, Colorado, United States
- McKee Medical Center — Loveland, Colorado, United States
- St. Mary - Corwin Regional Medical Center — Pueblo, Colorado, United States
- North Suburban Medical Center — Thornton, Colorado, United States
- Exempla Lutheran Medical Center — Wheat Ridge, Colorado, United States
- Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center — Hartford, Connecticut, United States
- Mayo Clinic - Jacksonville — Jacksonville, Florida, United States
- Illinois CancerCare - Bloomington — Bloomington, Illinois, United States
- St. Joseph Medical Center — Bloomington, Illinois, United States
- Graham Hospital — Canton, Illinois, United States
- Illinois CancerCare - Canton — Canton, Illinois, United States
- Aurora Presbyterian Hospital — Aurora, Colorado, United States
Full record on ClinicalTrials.gov
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