Effects of Intravenous Local Anesthetic on Bowel Function After Colectomy

Completed · Phase 3

Conditions studied: Postoperative Ileus

In brief

Epidural local anesthetics are the gold standard for shortening duration of bowel dysfunction after bowel surgery. Previous studies suggest that their effect may be in part a result of actions of the local anesthetic outside the epidural space. If local anesthetics could be administered intravenously instead, this might be a safer, easier and less expensive approach. Therefore, this trial will compare the effect on bowel function recovery of intravenous local anesthetics with those administered epidurally.

Key facts

Study ID

NCT00600158

Run by

University of Virginia

People needed

45

Starts

2005-04-01

Expected to finish

2006-07-01

Last updated by the study team

2008-01-24

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Informed consent
• Scheduled for colon tumor resection.
• American Society of Anesthesiologists (ASA) physical classification classes I, II, and III.

You may not qualify if…

• Age <18 or >75 years
• Allergy to local anesthetics
• Severe cardiovascular disease (myocardial infarction within 6 months, profoundly decreased left ventricular function (ejection fraction <40%), or high-grade arrhythmias) or liver disease (known AST or ALT or bilirubin >2.5 times the upper limit of normal)
• Systemic corticosteroid use
• Chronic use of opiates
• Unwillingness or contraindication to epidural analgesia.

Where it is running

• University of Virginia — Charlottesville, Virginia, United States

Full record on ClinicalTrials.gov

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