A Study To Compare Pregabalin/PF-00489791 Combination Versus Pregabalin Alone In Post-Herpetic Neuralgia

Completed · Phase 2 · Has a placebo group

Conditions studied: Postherpetic Neuralgia

In brief

Pregabalin is an alpha-2 delta ligand approved for the treatment of neuropathic pain, however, not all patients will respond to this drug. This study will compare the efficacy of pregabalin when administered with an experimental drug PF-00489791, in patients with post-herpetic neuralgia. The efficacy of this combination will be compared to pregabalin alone.

Key facts

Study ID

NCT00599638

Run by

Pfizer

People needed

72

Starts

2008-04-09

Expected to finish

2008-12-23

Last updated by the study team

2021-08-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female of non-childbearing potential
• Pain present for more than 3 months after healing of herpes zoster skin rash
• VAS score of >=40mm at screening and baseline visits

You may not qualify if…

• Patients with pain conditions which might impair the assessment of postherpetic neuralgia
• Skin conditions in the affected dermatome that could alter sensation other than postherpetic neuralgia
• History or diagnosis of DSM IV major depressive disorder

Where it is running

• North Alabama RadioPharmacy — Huntsville, Alabama, United States
• Tennessee Valley Pain Consultants — Huntsville, Alabama, United States
• River Region Research, LLC — Tallassee, Alabama, United States
• Radiant Research — Chandler, Arizona, United States
• Novara Clinical Research — Mesa, Arizona, United States
• Community Medical Providers — Clovis, California, United States
• Sierra Medical Research (Administrative only site) — Fresno, California, United States
• Prime-Care Clinical Research — Mission Viejo, California, United States
• Parkinson's Disease and Movement Disorders Center of Boca Raton — Boca Raton, Florida, United States
• Bradenton Research Center — Bradenton, Florida, United States
• Arthritis Associates of South Florida — Delray Beach, Florida, United States
• Delray Research Associates — Delray Beach, Florida, United States
• Office of Laszlo J Mate, M.D. — West Palm Beach, Florida, United States
• American Medical Research, Inc. — Oak Brook, Illinois, United States
• Beacon Clinical Research — Brockton, Massachusetts, United States
• ICPS Group — Norwood, Massachusetts, United States
• Neurological Research Center at Hattiesburg Clinic — Hattiesburg, Mississippi, United States
• CRC of Jackson — Jackson, Mississippi, United States
• Physician's Surgery Center — Jackson, Mississippi, United States
• Clinvest — Springfield, Missouri, United States
• Centennial Park Medical Building — North Platte, Nebraska, United States
• Neurology Associates of Great Plains — North Platte, Nebraska, United States
• Finger Lakes Clinical Research — Rochester, New York, United States
• North State Clinical Research, PLLC — Lenoir, North Carolina, United States
• The Center for Clinical Research — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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