Study to Determine if Avonex and Rebif Work Comparably Well in Subjects With Relapsing Multiple Sclerosis

Completed

Conditions studied: Multiple Sclerosis

In brief

The purpose of this study is to find out if weekly Avonex works as well as three times a week Rebif in subjects with relapsing multiple sclerosis.

Key facts

Study ID

NCT00599274

Run by

Biogen

People needed

136

Starts

2002-08-01

Expected to finish

2003-05-01

Last updated by the study team

2010-01-27

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Must have been receiving AVONEX® or Rebif®.
• Must have a confirmed diagnosis of relapsing-remitting MS using the Poser criteria.
• Must have experienced at least 2 relapses within the 3 year period prior to the initiation of treatment.
• Must have an EDSS score of 0.0 to 5.5, inclusive.

You may not qualify if…

• History of severe allergic or anaphylactic reaction or hypersensitivity to human albumin, to any interferon, or to other components of the drug formulation.
• History of poorly controlled hypertension and/or other clinically significant major disease.
• History of uncontrolled seizures within the 3 months prior to enrollment.
• History of suicidal ideation or an episode of severe depression within the 3 months prior to enrollment.
• Serious local infection or systemic infection within 8 weeks prior to enrollment.
• Treatment with certain other agents to treat MS symptoms or underlying disease.
• Treatment with any investigational product
• Previous participation in this study.
• Other Protocol-defined inclusion/exclusion criteria may apply.

Where it is running

• Research Site — Los Angeles, California, United States
• Research Site — Walnut Creek, California, United States
• Research Site — Shreveport, Louisiana, United States
• Research Site — Worcester, Massachusetts, United States
• Research Site — Charlotte, North Carolina, United States
• Research Site — Columbus, Ohio, United States
• Research Site — Edmonds, Washington, United States
• Research Site — Milwaukee, Wisconsin, United States
• Coordinating Research Site — Woodville, Australia
• Coordinating Research Site — Linz, Austria
• Coordinating Research Site — Halifax, Nova Scotia, Canada

Full record on ClinicalTrials.gov

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