Improving Functional Outcomes in Patients With Unilateral Vocal Cord Paralysis: Assessment of Adaptation Using Functional Magnetic Resonance Imaging

Completed · Not applicable

Conditions studied: Intrathoracic Malignancies, Unilateral Vocal Cord Paralysis

In brief

The purpose of this study is to see how the brain re-learns to control the larynx in speaking and swallowing when undergoing surgical rehabilitation in the form of either thyroplasty or vocal fold augmentation for unilateral vocal cord paralysis. What is needed is information on how the brain re-learns to control speaking and swallowing so that we can eventually learn how to help patients re-learn faster after their procedure. Functional Magnetic Resonance Imaging (or fMRI) will allow us to image your brain as you speak and swallow. We will produce "brain maps" for speaking, swallowing and hand movements.

Key facts

Study ID

NCT00597844

Run by

Memorial Sloan Kettering Cancer Center

People needed

20

Starts

2005-07-01

Expected to finish

2013-09-01

Last updated by the study team

2013-09-05

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients with UVCP undergoing type I thyroplasty or vocal fold augmentation for rehabilitation of speech and swallowing.
• Inclusion criteria for the healthy subjects:
• From age 18-85

You may not qualify if…

• for the UVCP patients includes the following:
• History of significant psychiatric condition (e.g. schizophrenia, obsessive-compulsive disorder, significant dementia),
• History of the following neurological conditions: CVA, seizure disorders, demyelinating conditions, systemic neuromuscular disorders, cerebral palsy, Alzheimer's disease.
• History of previous moderate to severe traumatic brain injury.
• History of significant cardiovascular, gastrointestinal or renal disease (e.g. myocardial infarction within the previous 12 months, significant vaso-occlusive disease, severe or advanced asthma, or renal compromise)
• History of achalasia
• History of dysphagia, odynophagia, or aphasia unrelated to present illness.
• History of significant claustrophobic reactions.
• Standard contraindications to MR examinations (e.g. implanted stimulators, pregnancy).
• Exclusion criteria for the healthy subjects includes the following:
• All of the conditions listed for the UVCP patients.
• Significant surgery or previous radiation therapy to the head and neck.
• History of other neoplasms involving the brain, head and neck, or gastrointestinal system.

Where it is running

• Memorial Sloan Kettering Cancer Center — New York, New York, United States

Full record on ClinicalTrials.gov

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