The Role of Genetic Polymorphisms in Innate Immune Response Genes in Susceptibility to Infections

Completed

Conditions studied: Infections

In brief

The purpose of this study is to better understand genetic susceptibility to infections and the interactions of specific genetic polymorphisms of innate immune receptors with microbial and fungal organisms. The goals of this study are: 1. Find out if some people are more likely to get severe infections, than others. To do this we will compare patients with leukemia who develop severe infections to patients who do not develop infections. 2. Find out if some people are more likely to develop lymphoma than others. To do this we will compare patients with lymphoma to people without lymphoma who are of the same sex and similar age and ethnic background to the patients with lymphoma.

Key facts

Study ID

NCT00597090

Run by

Memorial Sloan Kettering Cancer Center

People needed

319

Starts

2003-02-01

Expected to finish

2011-01-01

Last updated by the study team

2011-01-20

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subject must either:
• Have histologically confirmed acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), follicular or mantle cell lymphoma RA-EB, RAEB-T newly diagnosed at first or second remission AND are going to receive or have received myelosuppressive chemotherapy; OR
• Will receive or have received allogeneic HSCT for hematologic malignancy.
• Subject has signed informed consent before entering the study.
• Participation of children: For subjects under the age of 18, we will obtain the subject's and their parents' approval to enroll them.

You may not qualify if…

• Subject has been diagnosed with leukemia other than acute myeloid leukemia RA-EB or RAEB-T or acute lymphocytic.
• Subject is not going to receive chemotherapy or has not received chemotherapy.
• Subject will undergo/had undergone HSCT for disease other than hematologic malignancy.

Where it is running

• Memorial Sloan Kettering Cancer Center — New York, New York, United States

Full record on ClinicalTrials.gov

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