Cranberry for UTI Prevention in Residents of Long Term Care Facilities

Completed · Not applicable

Conditions studied: Urinary Tract Infection

In brief

Urinary tract infections (UTIs) affect over 7 million men and women per year and cost the health care industry over 1 billion dollars annually. The incidence of UTI increases markedly in elderly institutionalized persons and leads to excessive antimicrobial usage, emergency room visits, hospitalization, sepsis, and death. The use of antimicrobials to prevent UTI in elderly nursing home patients is not recommended and is fraught with problems such as adverse reactions, drug interactions, and the development of drug-resistant organisms. There is no accepted method of preventing UTI in residents of nursing homes, a vulnerable and understudied population with significant morbidity from UTI. The overall goal of this proposal is to conduct a prospective cohort pilot study that evaluates the feasibility of using cranberry to prevent UTI in nursing home residents. Each of the aims is critical for the optimal design of a larger placebo-controlled, definitive trial of cranberry for prevention of UTI in nursing home residents and will provide the essential preliminary data for future larger studies.

Key facts

Study ID

NCT00596635

Run by

Yale University

People needed

56

Starts

2007-01-01

Expected to finish

2008-08-01

Last updated by the study team

2013-03-29

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Greater than 60 years old and a resident of the nursing home or assisted living facility for greater than 30 days duration

You may not qualify if…

• Having a known major anatomic abnormality of the urinary tract
• Presence of acute UTI symptom
• Intolerance or allergy to cranberry products
• Current use of cranberry for prevention of UTI
• Use of warfarin
• History of kidney stones
• Presence of a chronic indwelling bladder catheter
• Dialysis dependence
• Chronic suppressive antibiotics
• Immunocompromised state due to hematological malignancies, HIV infection, chronic high dose (>10mg daily) prednisone or equivalent steroid use.

Where it is running

• Yale University School of Medicine, Internal Medicine, Section of Infectious Diseases — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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