Intrathecal Morphine on Transcranial Electric Motor-Evoked Potentials
Completed
Conditions studied: Trauma, Nervous System
In brief
Patients undergoing posterior spinal fusion (PSF) procedures for scoliosis are at risk for iatrogenic neurologic injury of the spinal cord and/or spinal nerve roots during surgical correction of the abnormal spinal curvature. The degree of neurologic injury can range from minor sensory deficits to complete paraplegia. Surgeons at CHOP utilize neurophysiologists to identify impending neurologic injury. These consultants monitor spinal cord pathways by recording and analyzing evoked potentials during the operation. Evoked potentials are low voltage electrical signals generated in response to transcranial or transcutaneous electrical stimulation of motor and sensory neural pathways. Some patients undergoing PSF receive an injection of morphine into the cerebrospinal fluid during the operation. This intrathecal (IT) morphine has potent analgesic effects. While most commonly used anesthetic agents have well-characterized effects on evoked potentials, little data exists on the effects of IT morphine on transcranial electric motor-evoked potentials (TceMEPs). This is a prospective observational study to characterize the effects of IT morphine on TceMEPs.
Key facts
- Study ID
- NCT00596609
- Run by
- Children's Hospital of Philadelphia
- People needed
- 36
- Starts
- 2007-08-01
- Expected to finish
- 2009-04-01
- Last updated by the study team
- 2009-09-16
Who can join
Age: 11 and older, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Intrathecal Morphine Group:
- All patients with idiopathic scoliosis aged 11 through and including 18 who present to CHOP for posterior spinal fusion will be eligible
- Patients with procedures anticipated to extend to or below the second lumbar vertebral level
- Only patients given intrathecal morphine after curve correction and instrumentation will be studied
- Control Group:
- All patients with idiopathic scoliosis aged 11 through and including 18 who present to CHOP for posterior spinal fusion will be eligible
- Patients with procedures not anticipated to extend to or below the second lumbar vertebral level
- Patients who do not receive IT morphine injection as part of their routine anesthetic care
You may not qualify if…
- Intrathecal Morphine Group:
- Patients who receive inhaled anesthetic agents before or during the 30 minutes following IT morphine injection
- Patients who receive neuromuscular blocking drugs within an hour before or during the 30 minutes following IT morphine injection.
- Patients who develop significant changes in TceMEPs prior to intrathecal morphine injection
- Patients with intraoperative hemodynamic instability which requires continuous vasoactive drug infusion (e.g., dopamine)
- Patients with neuromuscular, congenital, or other non-idiopathic scoliosis
- Pregnant or lactating females
- Control Group:
- Patients who receive inhaled anesthetic agents before or during the 30 minutes following IT morphine injection
- Patients who receive neuromuscular blocking drugs within an hour before or during the 30 minutes following IT morphine injection.
- Patients who develop significant changes in TceMEPs prior to the study interval
- Patients with intraoperative hemodynamic instability which requires continuous vasoactive drug infusion (e.g., dopamine)
- Patients with neuromuscular, congenital, or other non-idiopathic scoliosis
- Pregnant or lactating females
Where it is running
- The Children's Hospital of Philadephia — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.