Investigating Mucinase Activity in Airway Disease

Completed

Conditions studied: Asthma, Cystic Fibrosis

In brief

The purpose of this study is to investigate how mucus (phlegm or spit) is broken down once it forms in the airways (bronchial tubes) of people with lung disease. This research study will also examine whether blood groups have an effect on lung function or the type of mucus found in the lung. This study is not designed to be a treatment for asthma, emphysema, cystic fibrosis, or other lung disease. It is designed to help the investigators learn more about the causes of airway disease.

Key facts

Study ID

NCT00596232

Run by

University of California, San Francisco

People needed

211

Starts

2003-04-01

Expected to finish

2016-04-01

Last updated by the study team

2016-05-02

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Asthma:
• Male and female subjects aged 18 - 70 years
• Medical history consistent with asthma
• PC20 (provocative concentration causing a 20% fall) methacholine ≤ 8 mg/ml for subjects not taking inhaled corticosteroids
• PC20 methacholine ≤ 16 mg/ml for subjects taking inhaled corticosteroids
• Ability to provide informed consent
• Cystic Fibrosis:
• Male and female subjects aged 18-55 years
• Prior diagnosis of cystic fibrosis
• Ability to provide informed consent
• Healthy:
• Male and female subjects aged 18-70 years
• No current smoking history
• No history of asthma or allergic rhinitis
• FEV1 (forced expiratory volume in 1 second) > 80% predicted
• Ability to provide informed consent

You may not qualify if…

• Recent heart attack or stroke
• Known aortic or cerebral aneurysm
• Uncontrolled hypertension
• Pregnancy
• Lactation
• Lung disease other than asthma,cystic fibrosis, or chronic obstructive pulmonary disease (COPD)/emphysema/chronic bronchitis
• Upper- or lower-respiratory tract infection 6 weeks prior to study enrollment
• Significant asthma exacerbation 6 weeks prior to study enrollment
• Increasing hyposensitization therapy for the past 3 months

Where it is running

• UCSF Airway Clinical Research Center — San Francisco, California, United States

Full record on ClinicalTrials.gov

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