Neuropeptide Y (NPY) Regulation of Nociceptors

Completed

Conditions studied: Pain

In brief

Neuropeptide Y (NPY) potently inhibits pain neurons in rats, but does this occur in human pain neurons? This hypothesis will be tested using microdialysis probes in patients who elect to have root canal treatment or extraction of thier tooth.

Key facts

Study ID

NCT00596193

Run by

The University of Texas Health Science Center at San Antonio

People needed

11

Starts

2001-05-01

Expected to finish

2008-05-01

Last updated by the study team

2012-03-08

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• teeth with diagnosis of normal pulp or irreversible pulpitis
• mandibular teeth
• indication for either root canal or extraction of tooth
• age between 18-50

You may not qualify if…

• history of taking steroids within the last month
• history of hyperthyroidism, hypertension, asthma, uncontrolled or complicated Type-2 diabetes, drug abuse
• age less than 18 or greater than 50
• maxillary teeth

Where it is running

• University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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