Ketamine Versus Etomidate for Procedural Sedation for Pediatric Orthopedic Reductions

Completed · Phase 4

Conditions studied: Conscious Sedation Failure During Procedure

In brief

There are multiple retrospective studies detailing the use of etomidate in pediatric procedural sedation but few to no prospective clinical trials. None have compared etomidate to ketamine, currently the most commonly used sedative in the emergency department for pediatric procedural sedation. The investigators propose a randomized, controlled trial comparing etomidate versus ketamine for procedural sedation for fracture reduction for children presenting with extremity fracture requiring sedation for reduction. The investigators hypothesize that etomidate in combination with fentanyl will have similar reduction of distress and procedural recall as ketamine in combination with midazolam.

Key facts

Study ID

NCT00596050

Run by

Drexel University College of Medicine

People needed

50

Starts

2006-08-01

Expected to finish

2008-06-01

Last updated by the study team

2017-05-09

Who can join

Age: 5 and older, up to 18. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• age 5-18 years
• extremity fracture requiring reduction with sedation in emergency department

You may not qualify if…

• allergy to etomidate, midazolam, fentanyl, ketamine, lidocaine
• multi-system trauma
• history of psychosis
• pregnancy
• illicit drug use
• developmental delay
• non-english speaker

Where it is running

• St. Christopher's Hospital for Children — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.