Efficacy of Varenicline in Ambivalent Smokers

Completed · Phase 2 · Has a placebo group

Conditions studied: Tobacco Use Disorder, Tobacco Use Cessation, Nicotine Dependence

In brief

The purpose of this study is to test whether Varenicline can help ambivalent smokers (those who are interested in quitting at some point in the future but have no current plans to quit) to reduce their smoking and eventually quit.

Key facts

Study ID

NCT00595868

Run by

University of Vermont Medical Center

People needed

220

Starts

2008-03-01

Expected to finish

2010-01-01

Last updated by the study team

2011-12-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• At least 18 years old
• Able to get to research lab in Burlington, Vermont or Omaha, Nebraska
• Daily smoker
• Smoke at least 8 cigarettes per day
• No reduction in smoking in last 30 days
• No intention to quit in the next 30 days
• Never used Varenicline before
• Not currently using smoking cessation medications or nicotine replacement therapy
• Willing to use Varenicline for at least 2 weeks
• Fluent in English

You may not qualify if…

• Cannot be currently pregnant or breastfeeding
• Kidney disease
• Frequent nausea
• On certain medications for asthma and/or depression
• Another household member in study

Where it is running

• Nebraska Medical Center — Omaha, Nebraska, United States
• University of Vermont — Burlington, Vermont, United States

Full record on ClinicalTrials.gov

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