Effectiveness of Cognitive Behavioral Therapy for Treating Depression in People With Bipolar I Disorder

Completed · Not applicable

Conditions studied: Bipolar Disorder, Depression

In brief

This study will compare the effectiveness of cognitive behavioral therapy versus supportive psychotherapy in decreasing depression in people with bipolar disorder.

Key facts

Study ID

NCT00595387

Run by

Massachusetts General Hospital

People needed

54

Starts

2006-09-01

Expected to finish

2013-01-01

Last updated by the study team

2015-04-29

Who can join

Age: 18 and older, up to 64. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Normal or corrected-to-normal vision (tested by vision charts)
• Diagnosis of bipolar I disorder by the Mini International Neuropsychiatric Interview (MINI)
• HAM-D score of 17 or higher

You may not qualify if…

• Meets criteria for DSM-IV bipolar I disorder subtype rapid cycling
• Meets criteria for DSM-IV mixed episode
• Pregnant
• Serious medical illness
• Neurologic disorder and/or head trauma
• Current or past history of selected DSM-IV Axis I disorders other than bipolar disorder, including organic mental disorder, schizophrenia, delusional disorder, and psychotic disorders not otherwise specified
• Substance abuse or dependence within the 12 months prior to study entry and/or history of substance abuse for more than 12 months
• IQ of less than 80 on the Wechsler Adult Reading Test
• Previous treatment with CBT for depression
• Contraindications to MRI (e.g., metallic implants, claustrophobia)

Where it is running

• Massachusetts General Hospital Bipolar Clinic and Research Program — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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