Study of the Mechanisms of Asthma
Completed · Phase 1
Conditions studied: Asthma
In brief
The purpose of this study is to identify the causes of asthma that were not previously suspected, to better understand the effects of inhaled steroids on asthma and to identify new way to treat asthma. In order to take advantage of the most current scientific expertise, we (scientists at UCSF) plan to work together with Genentech Inc. We believe that working with Genentech will provide the best chance of developing new treatments for asthma.
Key facts
- Study ID
- NCT00595153
- Run by
- University of California, San Francisco
- People needed
- 127
- Starts
- 2007-04-01
- Expected to finish
- 2011-06-01
- Last updated by the study team
- 2014-01-20
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Group C:
- Male and female subjects between the ages of 18 and 70 years
- History of asthma
- Continuous treatment with inhaled corticosteroids for at least the 6-week
- Hyperreactivity to methacholine (provocative concentration of methacholine causing a 20% drop in forced expiratory volume in 1 second (PC20 FEV1) Methacholine ≤ 16.0 mg/mL).
You may not qualify if…
- History of asthma
- No use of oral or inhaled corticosteroids for the treatment of asthma in the past 6 weeks
- Hyperreactivity to methacholine (PC20 FEV1 Methacholine ≤ 8.0 mg/mL).
- At least one of the following symptoms, beta agonist use, or FEV1 criteria:
- Asthma symptoms on at least two days per week; OR
- Beta agonist use on at least two days per week; OR
- Forced expiratory volume in 1 second (FEV1) < 85% predicted
- Subjects must be non-smokers (patients who have never smoked or patients who have not smoked for 1 year and have a total pack-year smoking history < 15 packs).
Where it is running
- University of California, San Francisco — San Francisco, California, United States
Full record on ClinicalTrials.gov
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