Systemic Reactions to Allergen Immunotherapy Amd Skin Testing

Completed

Conditions studied: SYSTEMIC REACTION

In brief

Allergy skin tests and allergen immunotherapy are common procedures for both the diagnosis and treatment of atopic diseases. Allergen immunotherapy has proved to be effective in reducing the symptoms of allergic rhinitis and asthma1-2. Despite its clinical benefit, there is risk of systemic reactions associated with these procedures. The systemic reaction rate to skin testing for aeroallergens is significant lower than the rate of reactions to immunotherapy, but it is not negligible. Lin et al reported only 2 patients who had systemic allergic reactions to skin testing for respiratory allergies in 10,400 patients tested.3 They determined the overall risk of inducing anaphylactic reactions by skin testing to be less than 0.02% and other studies have produced similar results.4-5 The rate of systemic reactions to skin testing is likely underscored. Thompson et. al reported a systemic reaction rate of 6% of patients receiving skin testing.6 It is important to recognize the risk of systemic reactions seeing skin testing is commonly done. It is also imperative to recognize the treatments for these reactions to prevent progression. Hypothesis The systemic reaction rate to allergen immunotherapy and skin testing to aeroallergens is higher than previously reported. Biphasic anaphylactic reactions rarely occur with allergen immunotherapy and skin testing.

Key facts

Study ID

NCT00594802

Run by

University of South Florida

People needed

100

Starts

2006-08-01

Expected to finish

2007-06-01

Last updated by the study team

2010-08-09

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male and female subjects who are receiving skin testing or allergen immunotherapy from one allergy practice.

You may not qualify if…

• NON Male and female subjects who are receiving skin testing or allergen immunotherapy from one allergy practice.

Where it is running

• USF — Tampa, Florida, United States

Full record on ClinicalTrials.gov

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