Anti-Nephropathic Effects of Chronic Intermittent Intravenous Insulin Therapy (CIIIT)

Completed · Phase 3

Conditions studied: Diabetic Nephropathy, Diabetic Retinopathy

In brief

Investigators with the goal of optimizing glycemic and blood pressure control saw type 1 diabetic patients weekly. A control group received 3-4 subcutaneous insulin injections per day; an intravenous insulin pulsed infusion group received, in addition, three one hour infusions in a pulsatile fashion over one eight hour period each week. Patients were followed for 12 months with periodic testing of renal function by repeated blood and urinary analyses; diabetes control by blood testing and diabetes impact measurement score; cardiac and autonomic function by echocardiography, 24 hour electrocardiographic testing; and visual changes with repeated fundus photography. The study hypothesis was that correction of respiratory quotient would correct the defect leading to microvascular complications of diabetes (Type 1).

Key facts

Study ID

NCT00594152

Run by

Joslin Diabetes Center

People needed

71

Starts

1993-01-01

Expected to finish

1995-01-01

Last updated by the study team

2008-01-15

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Type 1 diabetics with proteinuria willing to be seen weekly for the evaluation of renal function

You may not qualify if…

• Associated active medical diseases that would not permit evaluation of stable renal disease over 18 months

Where it is running

• Joslin Diabetes Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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