Venovenous CO2 Removal (VVCO2R) in Patients With COPD and Acute Respiratory Failure
Stopped early · Not applicable
Conditions studied: Pulmonary Disease, Chronic Obstructive
In brief
The purpose of this study to determine the safety and effectiveness of a mechanical device to remove carbon dioxide from the blood of patients with chronic obstructive pulmonary disease (COPD)when they are hospitalized in the intensive care unit for exacerbation of their condition.
Key facts
- Study ID
- NCT00594009
- Run by
- The University of Texas Medical Branch, Galveston
- People needed
- 1
- Starts
- 2008-01-01
- Expected to finish
- 2011-03-01
- Last updated by the study team
- 2019-03-12
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Acute respiratory failure on invasive mechanical ventilation or
- Acute respiratory failure and an advanced directive foregoing invasive mechanical ventilation
- Established diagnosis of COPD
- Age group: 18 years or greater
You may not qualify if…
- Significant vasopressor support
- Systolic BP < 100 torr systolic despite vasopressor support
- Class III or Class IV congestive heart failure
- Left ventricular ejection fraction < 30% by previous echocardiogram
- Recent (6 month) history of myocardial infarction
- Coronary artery disease with unstable angina
- Recent (6 month) history of venous embolism
- Uncontrolled coagulopathy (international normalized ratio (INR) > 5 or activated partial thromboplastin time (aPTT) > 80s) despite corrective therapy
- History of heparin-induced thrombocytopenia or other adverse event following the administration of heparin (heparin group only)
- Pregnancy
- Severe chronic liver disease
- Severe anemia (Hgb < 9 gm/dl)
- Any contraindication to systemic anticoagulation with heparin, including recent central nervous system injury or hemorrhage, retinal hemorrhage or other recent hemorrhage from sites which cannot be controlled
- Technically unable to access vessels (obesity, limb deformity, previous surgery at the site, infection, etc.)
- Evidence of increased intracranial pressure or history of an intracranial hemorrhage within the past 3 months
Where it is running
- University of Texas Medical Branch — Galveston, Texas, United States
Full record on ClinicalTrials.gov
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