Innate Immunity and Respiratory Syncytial Virus (RSV) Infection in Children

Completed

Conditions studied: Respiratory Syncytial Virus Infection

In brief

In this project we will study the capacity for single nucleotide polymorphisms (SNP) in TLR4 gene to induce varying levels of inflammatory chemokine and cytokine production.

Key facts

Study ID

NCT00593918

Run by

University of Wisconsin, Madison

People needed

91

Starts

2003-11-01

Expected to finish

2008-06-01

Last updated by the study team

2015-10-20

Who can join

Age: any, up to 2. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Parental or sibling history of asthma.
• Child must be less than 24 months of age.
• Presence of viral upper or lower respiratory tract symptoms.

You may not qualify if…

• History of recurrent wheezing requiring systemic corticosteroids.
• Prior history of lung disease.
• Birth < 36 weeks gestation.
• Immunodeficiency
• Treatment with ribavirin, systemic or inhaled corticosteroids during the RSV infection.
• Congenital heart disease.
• No history of parental or sibling asthma.
• Less than 48 hour or more than 5 day duration of viral URI symptoms since the peak symptoms from RSV would be expected to occur from 2-5 days into course of infection.

Where it is running

• University of Wisconsin-Madison — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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