Comparison of Age-related Macular Degeneration Treatments Trials: Lucentis-Avastin Trial

Completed · Phase 3

Conditions studied: Age Related Macular Degeneration

In brief

The purpose of the study is to evaluate the relative efficacy and safety of treatment of neovascular AMD with Lucentis on a fixed schedule, Avastin on a fixed schedule, Lucentis on a variable schedule, and Avastin on a variable schedule. A five year follow-up visit is being conducted in 2014 to gather information on long term outcomes.

Key facts

Study ID

NCT00593450

Run by

University of Pennsylvania

People needed

1208

Starts

2008-02-01

Expected to finish

2015-04-01

Last updated by the study team

2017-08-21

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Active, subfoveal choroidal neovascularization (CNV)
• Fibrosis < 50% of total lesion area
• Visual acuity (VA) 20/25-20/320
• Age ≥ 50 yrs
• At least 1 drusen (>63μ) in either eye or late AMD in fellow eye

You may not qualify if…

• Previous treatment for CNV in study eye
• Other progressive retinal disease likely to compromise VA
• Contraindications to injections with Lucentis or Avastin

Where it is running

• Retinal Consultants of Arizona — Phoenix, Arizona, United States
• Retina Associates Southwest, P.C. — Tucson, Arizona, United States
• California Retina Consultants — Bakersfield, California, United States
• Retina-Vitreous Associates Medical Group — Beverly Hills, California, United States
• University of California-Davis Medical Center — Sacramento, California, United States
• Retinal Consultants Medical Group, Inc. — Sacramento, California, United States
• West Coast Retina Medical Group, Inc. — San Francisco, California, United States
• California Retinal Consultants — Santa Barbara, California, United States
• West Coast Retina Medical Group, Inc. — Walnut Creek, California, United States
• Colorado Retina Associates — Denver, Colorado, United States
• Retina Group of Florida — Fort Lauderdale, Florida, United States
• National Ophthalmic Research Institute — Fort Myers, Florida, United States
• Emory Eye Center — Atlanta, Georgia, United States
• Illinois Retina Associates — Flossmoor, Illinois, United States
• Ingalls Memorial Hospital/Illinois Retina Associates — Harvey, Illinois, United States
• Illinois Retina Associates — Joliet, Illinois, United States
• Midwest Eye Institute — Indianapolis, Indiana, United States
• University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
• Retina Associates of Kentucky — Lexington, Kentucky, United States
• University of Louisville School of Medicine — Louisville, Kentucky, United States
• Elman Retina Group, P.A. — Baltimore, Maryland, United States
• The Retina Group of Washington — Chevy Chase, Maryland, United States
• Retina Specialists — Towson, Maryland, United States
• Massachusetts Eye & Ear Infirmary — Boston, Massachusetts, United States
• Retina Consultants of Arizona — Mesa, Arizona, United States

Full record on ClinicalTrials.gov

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