Intraocular Pressure During Spine Surgery

Completed

Conditions studied: Intraocular Pressure

In brief

This study will compare the effect of two intravenous solutions on eye pressure during spine surgery in the following groups: Group A - Lactated Ringer's replacement for blood loss and placebo eye drops Group B - Lactated Ringer's replacement for blood loss and brimonidine eye drops Group C - Albumin replacement for blood loss and placebo eye drops Group D - Albumin replacement for blood loss and brimonidine eye drops

Key facts

Study ID

NCT00593359

Run by

The Cleveland Clinic

People needed

60

Starts

2007-12-01

Expected to finish

2010-02-01

Last updated by the study team

2016-02-23

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Spine surgery with instrumentation in prone position expected to last at least 5 hours;
• Anticipated blood loss ≥ 1L
• Age 18-80 years old;
• ASA physical status I-III.

You may not qualify if…

• History of increased intraocular pressure or glaucoma;
• Diabetic retinopathy;
• Heart failure or serious left ventricular dysfunction;
• Abnormal preoperative fundus examination;
• Creatinine > 2 mg/dL;
• Patient refuses blood transfusion or albumin administration

Where it is running

• Cleveland Clinic — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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