Assessment Of The Effects Of Short and Long Term Use Of CPAP

Stopped early · Not applicable · Has a placebo group

Conditions studied: Asthma

In brief

We hypothesize that the nocturnal use of continuous positive airway pressure in adults and children with asthma will decrease airway reactivity.

Key facts

Study ID

NCT00592631

Run by

Indiana University

People needed

27

Starts

2005-02-01

Expected to finish

2012-06-01

Last updated by the study team

2016-02-10

Who can join

Age: 8 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Inclusion criteria for children 8-18
• Children 8-18 years of age scheduled to start CPAP for obstructive sleep apnea.
• Subjects can have clinically stable asthma, with no plans by their physician to change asthma therapy over the next month
• Inclusion criteria adults 18-60
• Adults 18-60 years of age, seen in adult Pulmonary Clinic for sleep related problems who may require treatment with nocturnal continuous positive pressure (CPAP), which will be determined by polysomnography(PSG) will be approached to participate in the study.

You may not qualify if…

• Exclusions for Children category age 8-18 include:
• Cyanotic congenital heart disease.
• History of acute respiratory symptoms for 3 weeks prior to testing.
• Inability to perform pulmonary function testing adequately.
• Escalation in asthma medication at time of recruitment.
• SaO2 <93% while awake and breathing room air
• Baseline FEV1 <75% predicted
• Exclusions for adults 18-60 include:
• Gastro-Esophageal Reflux requiring Medical management.
• Chronic Obstructive Pulmonary Disease.
• Use of Supplemental Oxygen.
• Ischemic Heart Disease or Hypertension requiring treatment with medications other than diuretics.
• Use of systemic corticosteroid therapy during the past 6 months.
• Acute Respiratory Illness in the previous 8 weeks.
• Exclusions/Inclusion criteria for adults with asthma include:
• Juniper Score <1.5
• Baseline FEV1 > or equal to 70%
• Non-smoking for 6 months
• Less than 10 pack year smoking history
• No change in asthma medications for the last 2 months
• Negative pregnancy test
• Subject cannot have sleep apnea

Where it is running

• Riley Hospital for Children — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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