Hypoglycemia Associated Autonomic Failure in Type 1 DM, Q2

Completed · Not applicable

Conditions studied: Type 1 Diabetes

In brief

Alprazolam (Xanax) will blunt the body's ability to defend itself from low blood sugar.

Key facts

Study ID

NCT00592332

Run by

Vanderbilt University

People needed

56

Starts

2005-06-01

Expected to finish

2009-06-01

Last updated by the study team

2014-12-11

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 16 (8 males, 8 females) Type 1 diabetes patients aged 18-45 yr.
• 16 (8 males, 8 females) healthy controls aged 18-45 yr.
• HbA1c > 7.0% (Type 1 diabetes patients)
• Had diabetes for 2-15 years (Type 1 diabetes patients)
• No clinical evidence of diabetic tissue complications (Type 1 diabetes patients)
• Body mass index 21-30 kg · m-2
• Normal bedside autonomic function
• Normal results of routine blood test to screen for hepatic, renal, and hematological abnormalities
• Female volunteers of childbearing potential: negative HCG pregnancy test

You may not qualify if…

• Prior history of poor health: any current or prior disease condition that alters carbohydrate metabolism and prior cardiac events and/or evidence for cardiac disease
• Hemoglobin of less than 12 g/dl
• Abnormal results following screening tests
• Pregnancy
• Subjects unable to give voluntary informed consent
• Subjects with known liver or kidney disease
• Subjects taking steroids
• Subjects taking beta blockers
• Subjects on anticoagulant drugs, anemic, or with known bleeding diseases

Where it is running

• Vanderbilt University — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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