Effect of Medium Chain Fatty Acids on Cognitive Function During Acute Hypoglycemia in Patients With Type 1 Diabetes

Completed · Not applicable · Has a placebo group

Conditions studied: Diabetes Mellitus, Type 1

In brief

At present, there are no therapeutic agents that can minimize severe hypoglycemia (low blood sugar) and its effects on long-term brain function. The aim of this study is to determine whether the human brain is able to use medium chain fatty acids (MCFA) and/or their metabolites as an alternative fuel source during acute hypoglycemia in patients with Type 1 Diabetes Mellitus (T1DM). The hypothesis is that medium chain fatty acids will provide a rapidly absorbed, non-carbohydrate fuel that will improve cognitive performance during episodes of hypoglycemia (low blood sugar.)

Key facts

Study ID

NCT00592072

Run by

Yale University

People needed

12

Starts

2005-07-01

Expected to finish

2008-07-01

Last updated by the study team

2015-01-22

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Type 1 Diabetes Mellitus for greater than 5 years (C-peptide negative)
• Age 18-55 years
• Subject is on intensive insulin therapy resulting in a Hemoglobin A1c of less than 7.5%
• History of frequent hypoglycemic events as defined as having at least one blood glucose of less than 60 mg/dl in the last four weeks

You may not qualify if…

• History of hypoglycemia induced seizures
• Pregnancy
• Significant baseline anemia (hemoglobin < 11.0g/dl or hematocrit < 33%)
• A history of liver cirrhosis or porto-caval shunt surgery

Where it is running

• Yale University School of Medicine — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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