A Model for Genetic Susceptibility: Melanoma
Running, not enrolling
Conditions studied: Melanoma, Skin Cancer
In brief
The goal of this study is to find out if some people are more likely to get melanoma, a form of skin cancer, than others are. To do this we will compare people who have had more than one melanoma to people who have had only one melanoma and to people who are similar but who have not developed melanoma. People respond to the environment in different ways. Some may be born with genes that make them more likely to get this type of skin cancer. Each person has many ways to repair normal damage to their genes. Specific genes may affect the repair of sun damage. Other genes affect the way the skin itself reacts to the sun. We want to find out which genes have normal changes in them and lead to different responses to exposures, such as the sun. We also want to find out if sun habits are related to the way these genes work.
Key facts
- Study ID
- NCT00591500
- Run by
- Memorial Sloan Kettering Cancer Center
- People needed
- 4082
- Starts
- 1999-11-01
- Expected to finish
- 2027-07-01
- Last updated by the study team
- 2026-08-05
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- The subject must have a histologically confirmed invasive first primary melanoma newly diagnosed between January 1, 2000 and December 31, 2000.
- OR the subject must have a histologically confirmed invasive or in situ second primary melanoma newly diagnosed between January 1, 1998 and December 31, 2003. One of the earlier primaries must be invasive melanoma OR the subject must be a randomly ascertained control from the general.
- The patient must be a resident of a one of the specific geographic areas participating in this study.
You may not qualify if…
- Subjects who do not speak English or Italian
- Subject is unable to sign informed consent
- Subject is unable to participate in telephone interview
Where it is running
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
Full record on ClinicalTrials.gov
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