New Therapy of Laryngeal Papilloma In Children

Stopped early · Not applicable · Has a placebo group

Conditions studied: Papilloma

In brief

This study will determine efficacy of a new and combined treatment of laryngeal recurrent respiratory papillomatosis (RRP), by using a 585 nm pulsed dye laser (PDL) and a dietary supplement, diindolylmethane (DIM). We will compare this new treatment with PDL-only, in a total of 30 children (15 of each treatment), to determine whether this combined treatment would be effective and safe in preventing the RRP recurrence. This is the first study to combine PDL technique with DIM, to develop a new, voice-preserving and long-term effective method of managing laryngeal RRP in children.

Key facts

Study ID

NCT00591305

Run by

Boston University

People needed

1

Starts

2007-09-01

Expected to finish

2011-10-01

Last updated by the study team

2017-05-18

Who can join

Age: 10 and older, up to 21. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 10 to 21 years of age
• laryngeal papillomas requiring surgical treatment
• willingness to participate in the study
• a signed informed consent form by guardian or parent

You may not qualify if…

• age less than 10 year old, or older than 21 year
• guardian or parent does not understand or can not sign the consent form
• malignant diseases such as laryngeal cancer
• history of being hypersensitive to cabbage or other cruciferous vegetables
• pregnancy

Where it is running

• Boston Medical Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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