Normal Reference Ranges for Urinary Metabolites and Supersaturation Indices in Pediatric Populations
Completed
Conditions studied: Healthy
In brief
The reported normal values used in diagnosing and treating pediatric kidney stone formers are based on adult values or historic data from small studies. Urinary supersaturation indices which are now described in the adult stone literature as more sensitive predictors of stone composition, and precise predictors of response to therapy, are not established in children. The goals of this prospective study are to redefine normal values for pediatric urinary metabolites and supersaturation indices based on samples from a large number of healthy children and to identify if a difference in urinary supersaturations in children is protective.
Key facts
- Study ID
- NCT00591097
- Run by
- University of Wisconsin, Madison
- People needed
- 300
- Starts
- 2006-10-01
- Expected to finish
- 2011-10-01
- Last updated by the study team
- 2013-12-18
Who can join
Age: 3 and older, up to 18. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy male and female children between the ages of 3 and 18, inclusive, of all races who are toilet trained and who can submit a 24-hour urine sample
You may not qualify if…
- Active urinary tract infection
- Known urologic anatomic abnormality
- Personal or first-degree relative family history of urolithiasis or metabolic abnormality known to lead to urinary stone development
- Renal insufficiency
- Inability to collect a 24-hour urine specimen
- Intake of medications known to alter the risk of stone development such as steroids or diuretics or vitamins or calcium supplementation exceeding recommended daily allowances
- Adherence to restrictive diet for medical reasons
- Inflammatory or absorptive bowel disease
Where it is running
- University of Wisconsin Hospital and Clinics — Madison, Wisconsin, United States
- Charles Durkee, MD — Milwaukee, Wisconsin, United States
Full record on ClinicalTrials.gov
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