Clinical and Molecular-Metabolic Phase II Trial of Perifosine for Recurrent/Progressive Malignant Gliomas

Completed · Phase 2

Conditions studied: Malignant Gliomas, CNS, Brain Cancer, Cancer

In brief

The purpose of this study is to test the effectiveness of perifosine in preventing further tumor growth using the established optimal dose of the drug. A second goal is to determine if perifosine can block the molecules in the tumor that drive it to divide and grow.

Key facts

Study ID

NCT00590954

Run by

Memorial Sloan Kettering Cancer Center

People needed

32

Starts

2006-05-01

Expected to finish

2019-11-11

Last updated by the study team

2020-10-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must have shown unequivocal evidence for tumor progression by MRI or CT scan.
• Patients must be on a stable or decreasing dose of corticosteroids for a minimum of 5 days before the baseline MRI and PET scans.
• Patients must have failed prior radiation therapy.
• Patients with prior therapy that included interstitial brachytherapy or stereotactic radiosurgery (including gamma-knife or cyber-knife) must have confirmation of true progressive disease rather than radiation necrosis based upon either PET or Thallium scanning, and/or MR spectroscopy, and/or MR Perfusion, and/or surgical documentation of disease.
• All patients must sign an informed consent indicating that they are aware of the investigational nature of this study. Patients must have signed an authorization for the release of their protected health information.
• Age > 18 years old, and with a life expectancy > 8 weeks.
• Karnofsky Performance Status ≥ 50%
• Patients must have recovered from all acute toxicities from prior therapies. At least 28 days must have elapsed since prior radiation.
• Patients must have adequate bone marrow function
• Patients must agree to practice adequate contraception.

You may not qualify if…

• Patients must not be taking EIAEDs
• Patients must not have any significant medical illnesses or other history that in the investigator's opinion cannot be adequately controlled with appropriate therapy or would compromise the patient's ability to tolerate this therapy.
• Patients with a history of any other cancer (except non-melanoma skin cancer or carcinoma in-situ of the cervix), unless in complete remission and off of all therapy for that disease for a minimum of 3 years are ineligible.
• Patients must not have active infection or serious intercurrent medical illness.
• HIV-Positive patients receiving combination anti-retroviral therapy are excluded from the study due to possible retro-viral drug interactions.
• Patients must not have any disease that will obscure toxicity or dangerously alter drug metabolism.

Where it is running

• Memorial Sloan-Kettering Cancer Center — New York, New York, United States

Full record on ClinicalTrials.gov

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