Augmentation in Tx-resistant OCD: an Open Label Trial
Completed
Conditions studied: Obsessive Compulsive Disorder
In brief
This study examines the use of Acamprosate (Campral(R)) in the treatment of Obsessive Compulsive Disorder (OCD). The treatment of this condition is difficulty and a large percentage of patients fail to respond to medications and have residual symptoms. Such patients are referred to as having treatment resistant OCD.
Key facts
- Study ID
- NCT00590642
- Run by
- Creighton University
- People needed
- 30
- Starts
- 2006-04-01
- Expected to finish
- 2009-10-01
- Last updated by the study team
- 2009-12-01
Who can join
Age: 19 and older, up to 55. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Men and women between 19-55 years of age
- have dx of OCD as determined by the structured clinical interview for DSM-IV axis 1 disorders
- SSRI resistant patients with OCD
- Subjects who are able to comprehend and satisfactorily comply with protocol requirements and have ability to read and write English.
- Signed written informed consent prior to entering any study procedures.
- Concomitant psychotropic medications permitted only if prescribed at stable dose for at least 1 month before screening visit
You may not qualify if…
- Patients with concurrent DSM-IV diagnosis of delirium, dementia, amnestic and other cognitive disorders
- Patients with concurrent DSM-IV diagnosis of mental retardation
- Patients with concurrent DSM-IV diagnosis of lifetime schizophrenia and other psychotic disorders
- Patients with concurrent DSM-IV diagnosis of lifetime bipolar disorder
- Substance dependence or abuse (excluding nicotine) within 6 months prior to screening visit
- Patients with score of less than 16 on Y-BCOS during screening.
- Patients with history of intolerance or hypersensitivity to acamprosate.
- Patients based on history or mental status exam have significant risk fo committing suicide.
- Patients who are homicidal or violent.
- Patients with severe renal impairment
- Female patients who are pregnant or lactating
- Subjects with history of psychosurgery for OCD
Where it is running
- Creighton University Department of Psychiatry — Omaha, Nebraska, United States
Full record on ClinicalTrials.gov
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