Dietary Salt Intake and Vascular Function

Completed · Early Phase 1

Conditions studied: Healthy

In brief

The purpose of this study is to look at the effects of high- and low-salt diets on blood vessel function in healthy subjects.

Key facts

Study ID

NCT00590512

Run by

Brigham and Women's Hospital

People needed

133

Starts

2005-03-01

Expected to finish

2012-11-01

Last updated by the study team

2013-08-29

Who can join

Age: 18 and older, up to 35. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Healthy male, African-American volunteers
• 18-35 years of age,
• No personal or first degree relative with hypertension or diabetes,
• Blood pressure <130/85 mmHg and > 90/60 at the screening visit,
• Body mass index <30 kg/m2,
• No clinically significant abnormalities on screening tests (complete blood count, serum electrolytes, liver enzymes, thyroid stimulating hormone, urinalysis and electrocardiogram).

You may not qualify if…

• Alcohol intake >2 beverage/night,
• Smoking,
• Recreational drug use,
• Personal history of coronary disease, diabetes, hypertension, stroke, kidney disease, or illness requiring overnight hospitalization in the past 6 months,
• Prescription or herbal medication use,
• Ischemic changes on resting electrocardiogram,
• Known hypersensitivity to any of the study drugs,
• Other active medical problems detected by examination or laboratory testing.

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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