Ondansetron vs Prochlorperazine for Nausea and Vomiting in the Emergency Department

Completed · Phase 2

Conditions studied: Nausea and Vomiting

In brief

This study will compare the effect of prochlorperazine and ondansetron for the treatment of nausea and vomiting in the emergency department.

Key facts

Study ID

NCT00590317

Run by

Emory University

People needed

64

Starts

2005-03-01

Expected to finish

2008-09-01

Last updated by the study team

2014-05-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients presenting to the ED with at least one of the following
• Nausea
• Vomiting documented in the ED

You may not qualify if…

• Previous treatment in the ED with Ondansetron, prochlorperazine, promethazine or metaclopramide
• Patients with missed last menstrual period
• Pregnancy
• Age < 18 years old
• Treatment with antineoplastic agents within 7 days prior to randomization
• Irritable bowel syndrome
• Gastroparesis
• Suspected gastrointestinal bleed
• Suspected intestinal obstruction
• Preexisting motor disorder (Restless-leg syndrome or Parkinson's disease)
• Traumatic brain injury upon admission to ED
• Intracranial hemorrhage upon admission to ED
• Patients unable to read, write or communicate in the English language
• Patients leaving the ED against medical advice

Where it is running

• Grady Hospital — Atlanta, Georgia, United States
• Grady Memorial Hospital — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

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