T-Wave Alternans in Acute Myocardial Infarction: An Evaluation of the Time of Testing on Its Prognostic Accuracy
Completed
Conditions studied: Myocardial Infarction, Arrhythmias
In brief
T-wave alternans is an electrocardiographic finding that has been shown to predict the occurrence of future cardiac arrhythmias in patients who have had a heart attack. What is unknown about T-wave alternans testing is when is the best time to perform the test. In most studies, T-wave alternans testing is conducted 4 weeks or more after a heart attack. It is unknown if T-wave alternans testing performed prior to hospital discharge in heart attack patients is reliable. The objective of this project is to determine the diagnostic accuracy of T-wave alternans testing performed prior to hospital discharge and again at 30 days after hospital discharge in patients who have suffered a heart attack.
Key facts
- Study ID
- NCT00589849
- Run by
- Creighton University
- People needed
- 32
- Starts
- 2006-05-01
- Expected to finish
- 2011-05-01
- Last updated by the study team
- 2011-10-05
Who can join
Age: 19 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Acute Myocardial Infarction (MI) confirmed by electrocardiographic and or/ enzymatic criteria
- Patients with a left ventricular ejection fraction of 45% or less
You may not qualify if…
- Patients with (1) atrial fibrillation, (2) pacemaker rhythm, (3) left bundle branch block, (4) class III-IV heart failure, (5) inability to achieve a target heart rate with exercise or handgrip stress or (6) spontaneous sustained ventricular tachycardia/ventricular fibrillation will be excluded
- Patients with recurrent angina pectoris, MI, coronary revascularization, or any other adverse cardiovascular event in the 30 days following their initial MI will also be excluded
Where it is running
- Creighton University Medical Center — Omaha, Nebraska, United States
Full record on ClinicalTrials.gov
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