Antibiotics and the Prolongation of Pregnancy in Preterm Labor With an Advanced Cervical Exam

Stopped early · Not applicable · Has a placebo group

Conditions studied: Length of Pregnancy Prolongation in Hours

In brief

Preterm birth remains a major health concern affecting up to 12% of all live births prior to 37 weeks gestation. As preterm birth can often be associated with infection our proposal is to evaluate in a randomized fashion antibiotics for women with advanced cervical exams.

Key facts

Study ID

NCT00589329

Run by

MetroHealth Medical Center

People needed

20

Starts

2007-12-01

Expected to finish

2012-10-01

Last updated by the study team

2019-09-04

Who can join

Age: 18 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• All patients admitted with the diagnosis of preterm labor between 24 0/7 and 33 6/7 weeks gestation. Preterm labor will be defined by regular contractions and/or cervical change from last documented exam.
• Cervical exam 4 cm or greater
• Intact membranes

You may not qualify if…

• Multiple gestation (>2)
• Clinical evidence of chorioamnionitis, such as maternal fever, uterine tenderness, fetal tachycardia
• Lethal fetal anomaly
• Persistent vaginal bleeding, abruption, or placenta previa
• Rupture of membranes
• Maternal illness or fetal indication requiring delivery
• Inability to give informed consent
• Serious allergy to study medications. GI discomfort will not be considered a drug allergy

Where it is running

• MetroHealth Medical Center — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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