Comparison of A Mobile-Bearing Total Knee System With A Fixed-Bearing Total Knee System In Cemented Total Knee Arthroplasty

Completed · Not applicable

Conditions studied: Degenerative Joint Disease

In brief

Pain, weakness, instability, and progressive dysfunction are the hallmarks of arthritis of the knee. Total knee replacement may frequently be the only therapeutic intervention to provide adequate improvement in pain and function. Both fixed bearing and mobile bearing knees have a long track record of clinical success. Mobile bearing designs have theoretical advantages of decreased contact stresses on the tibial tray, decreased polyethylene wear, and improved range of motion relative to fixed bearing designs. These theoretical advantages may become especially important in the young patient who requires a knee arthroplasty. This study will attempt to see if there is a clinical difference in outcome between mobile bearing and fixed bearing knee arthroplasties in patients who require total knee replacement.

Key facts

Study ID

NCT00589108

Run by

Mayo Clinic

People needed

240

Starts

2001-01-01

Expected to finish

2011-05-01

Last updated by the study team

2013-01-16

Who can join

Age: 40 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients undergoing unilateral primary knee surgery for degenerative joint disease (DJD).

You may not qualify if…

• Severe deformity greater than or equal to 20 degrees varus, valgus malalignment
• Osteomyelitis, septicemia, or other active infections that may spread to other areas of the body
• The presence of infections, highly communicable diseases, e.g., AIDS, active tuberculosis, venereal disease, hepatitis
• Significant neurological or musculoskeletal disorders or disease that may adversely affect normal gait or weight bearing
• Metastatic disease
• Any congenital, developmental, or other bone disease or previous knee surgery that may, in the surgeon's judgement, interfere with total knee prosthesis survival or success, e.g., Paget's disease, Charcot's disease secondary to diabetes, severe osteoporosis, previous high tibial osteotomy, etc.
• Presence of previous prosthetic knee replacement device (any type)
• Arthrodesis of the affected knee
• Patients not requiring patella resurfacing.

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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