Irinotecan and Cediranib in Treating Patients With Metastatic Colorectal Cancer That Did Not Respond to Previous Oxaliplatin, Fluoropyrimidine, and Bevacizumab
Stopped early · Phase 2
Conditions studied: Colorectal Cancer
In brief
RATIONALE: Drugs used in chemotherapy, such as irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Cediranib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving irinotecan together with cediranib may kill more tumor cells. PURPOSE: This phase II clinical trial is studying how well giving irinotecan together with cediranib works in treating patients with metastatic colorectal cancer that did not respond to previous oxaliplatin, fluoropyrimidine, and bevacizumab.
Key facts
- Study ID
- NCT00588900
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 5
- Starts
- 2008-03-01
- Expected to finish
- 2011-11-01
- Last updated by the study team
- 2017-04-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Evanston Hospital — Evanston, Illinois, United States
- Elkhart Clinic, LLC — Elkhart, Indiana, United States
- Elkhart General Hospital — Elkhart, Indiana, United States
- Fort Wayne Medical Oncology and Hematology — Fort Wayne, Indiana, United States
- Howard Community Hospital — Kokomo, Indiana, United States
- Center for Cancer Therapy at LaPorte Hospital and Health Services — La Porte, Indiana, United States
- CCOP - Northern Indiana CR Consortium — South Bend, Indiana, United States
- Memorial Hospital of South Bend — South Bend, Indiana, United States
- Michiana Hematology-Oncology, PC - South Bend — South Bend, Indiana, United States
- Saint Joseph Regional Medical Center — South Bend, Indiana, United States
- South Bend Clinic — South Bend, Indiana, United States
- Hematology Oncology Associates of the Quad Cities — Bettendorf, Iowa, United States
- Holden Comprehensive Cancer Center at University of Iowa — Iowa City, Iowa, United States
- Lakeland Regional Cancer Care Center - St. Joseph — Saint Joseph, Michigan, United States
- Lakeside Cancer Specialists, PLLC — Saint Joseph, Michigan, United States
- Ellis Fischel Cancer Center at University of Missouri - Columbia — Columbia, Missouri, United States
- Cancer Resource Center - Lincoln — Lincoln, Nebraska, United States
- CCOP - Missouri Valley Cancer Consortium — Omaha, Nebraska, United States
- Immanuel Medical Center — Omaha, Nebraska, United States
- Alegant Health Cancer Center at Bergan Mercy Medical Center — Omaha, Nebraska, United States
- Creighton University Medical Center — Omaha, Nebraska, United States
- New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care — Concord, New Hampshire, United States
- New Hampshire Oncology - Hematology, PA - Hooksett — Hooksett, New Hampshire, United States
- Lakes Region General Hospital — Laconia, New Hampshire, United States
- CCOP - Hematology-Oncology Associates of Central New York — East Syracuse, New York, United States
Full record on ClinicalTrials.gov
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