Capsaicin Cough Threshold in Chronic Cough Due to Postnasal Drip
Completed
Conditions studied: Post Nasal Drip
In brief
This study is being done to find out why some people with mucus dripping down the back of their throat have a nagging cough while others do not cough.
Key facts
- Study ID
- NCT00588627
- Run by
- Mayo Clinic
- People needed
- 25
- Starts
- 2006-03-01
- Expected to finish
- 2008-12-01
- Last updated by the study team
- 2010-03-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Postnasal Drip with chronic cough:
- Postnasal drip by rhinoscopy
- Cough by visual analog scale.
- Patients have to be 18 years old or older.
- Cough-variant asthma must be excluded by a negative methacholine challenge test within one year, or documented failure of chronic cough to resolve after administration of inhaled corticosteroid (> one-month duration). Asthma is defined by the ATS guidelines.
- Subjects must have a negative chest radiogram or Chest CT scan within 6 months.
- No active GERD symptoms (< 7 RSI score) \& a stable dose of Proton Pump Inhibitor (4 weeks).
- Eligibility Criteria of Postnasal Drip without cough:
- Postnasal drip by rhinoscopy
- No cough by visual analog scale.
- Patients have to be 18 years old or older.
You may not qualify if…
- Subject Exclusion Criteria for Postnasal Drip with Chronic Cough:
- Presence of nasal polyposis and/or sinusitis or active GERD symptoms on examination.
- Current smokers (smoking within the 2 months prior to the study) will be excluded.
- Patients with an upper respiratory tract infection within the preceding 8 weeks.
- Patients taking angiotensin converting enzyme inhibitors.
- Patients on leukotriene receptor antagonist and/ or nasal topical corticosteroids or inhaled corticosteroids. Patient must be off nasal or inhaled corticosteroid by at least 4 weeks.
- Exclusion Criteria: Same for Post Nasal Drip without cough except:
- A chest radiogram is not necessary in this group.
- Patients taking leukotriene inhibitors, or using nasal steroid therapy.
Where it is running
- Mayo Clinic — Rochester, Minnesota, United States
Full record on ClinicalTrials.gov
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