Effect of Acute Statin Treatment in Patients Undergoing Percutaneous Coronary Intervention

Stopped early · Not applicable · Has a placebo group

Conditions studied: Coronary Artery Disease

In brief

The goal of this study is to determine if one dose of simvastatin will decrease the inflammatory response to coronary intervention. Also to determine if one dose of simvastatin affects endothelial function (activity of the artery) as measured by noninvasive peripheral artery tonography.

Key facts

Study ID

NCT00588471

Run by

Mayo Clinic

People needed

57

Starts

2002-11-01

Expected to finish

2011-04-01

Last updated by the study team

2012-11-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients undergoing PCI/angiography
• No previously known side effects of statins
• Patients who sign an informed consent
• Age > 18 years old

You may not qualify if…

• Patients with ST elevation myocardial infarction
• Patients with cardiogenic shock
• Patients with hypersensitivity to statins
• Patients with unexplained muscle pain
• Patients with acute liver disease
• Patients receiving cyclosporine, antifungal azoles, macrolide antibiotics, niacin, fibrates> 1 quart grapefruit juice/day or nefazodone
• Patients with creatinine > 2.0
• Patients with known malignancy
• Ejection Fraction < 25%
• No coronary care unit patients
• No outpatients

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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