Epidural Clonidine for Lumbosacral Radiculopathy

Stopped early · Not applicable

Conditions studied: Lumbar and Other Intervertebral Disc Disorders With Radiculopathy

In brief

This was a randomized, blinded study of transforaminal epidural injection of clonidine versus a similar injection of corticosteroid for acute lumbosacral radiculopathy. The hypothesis was that clonidine will be as effective as steroid for this condition.

Key facts

Study ID

NCT00588354

Run by

Mayo Clinic

People needed

26

Starts

2006-10-01

Expected to finish

2009-02-01

Last updated by the study team

2012-01-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Residents 18 years or older of Olmsted or contiguous counties and identified as having an acute unilateral radicular syndrome of less than 3 months duration (leg pain>back, discogenic cause, one or more of the following:
• Positive Straight Leg Raise (SLR) test
• Myotomal weakness
• Dermatomal sensory loss) and with concordant
• Confirmatory findings on recent MRI or CT myelogram

You may not qualify if…

• History of recent spinal trauma
• Cauda equina syndrome (This is a serious neurologic condition in which there is acute loss of function of the lumbar plexus, neurologic elements of the spinal canal below the termination of the spinal cord.)
• Progressive neurological deficit
• Motor deficit
• Pathological or infectious etiology
• Involvement in workers' compensation claim
• History of adverse reaction to corticosteroids, local anesthetic or clonidine
• History of one or more corticosteroid injection(s) (equivalent to 40 mg of triamcinolone acetate) in the preceding 4 months
• Pregnant
• Severe medical disease

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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