Preoperative Gabapentin for Acute and Chronic Post-thoracotomy Analgesia
Completed · Not applicable · Has a placebo group
Conditions studied: Pain
In brief
One dose of either gabapentin or placebo will be given to patients prior to thoracotomy. Patients will also receive an epidural infusion, intravenous patient-controlled analgesia with fentanyl, oral acetaminophen and intravenous ketorolac as needed to achieve optimal analgesia. Pain ratings and supplemental medication use will be recorded for 48 hours and will also be assessed at 3 months postoperatively to determine whether the patients who received gabapentin had improved analgesia and/or required less supplemental medication than the placebo group.
Key facts
- Study ID
- NCT00588159
- Run by
- Michelle Kinney
- People needed
- 146
- Starts
- 2007-06-01
- Expected to finish
- 2010-03-01
- Last updated by the study team
- 2016-05-04
Who can join
Age: 45 and older, up to 75. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 45-75 years
- Undergoing thoracotomy (lobectomy, segmentectomy, wedge resection)
You may not qualify if…
- Undergoing chest wall resection, gastroesophageal surgery
- Enrolled in another post-thoracotomy analgesic research protocol
- Pre-existing pain syndrome
- Current gabapentin or pregabalin therapy
- Inability to understand the study protocol
- Coagulopathy
- Current use of anticoagulants
- Allergy to medications on protocol
- Creatinine >1.3
- Moderate or severe aortic stenosis
- Severe psychological disorders
- Bacteremia, osteomyelitis, or infection at site of thoracic epidural placement
- History of previous thoracotomy
- Patient declines preoperative epidural catheter placement
- Prisoners or other institutionalized individuals
- Severe hepatic, renal or cardiovascular disorders
- Women who can become pregnant
Where it is running
- Mayo Clinic — Rochester, Minnesota, United States
Full record on ClinicalTrials.gov
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