Enteric Oxalate Absorption Study in Unclassified Hyperoxaluria

Completed · Phase 1

Conditions studied: Enteric Hyperoxaluria, Hyperoxaluria

In brief

The purpose of this study is to learn more about a condition called 'unclassified hyperoxaluria'. People with this condition have large amounts of oxalate in their urine, which can cause kidney stones and kidney failure. We do not know what causes the high level of oxalate in the urine. In this study, we will evaluate absorption of a test dose of oxalate taken orally by measuring the amount of the test dose that is eliminated in the urine. We will compare the results of affected patients to healthy volunteers.

Key facts

Study ID

NCT00588120

Run by

Mayo Clinic

People needed

114

Starts

1998-12-01

Expected to finish

2020-01-01

Last updated by the study team

2020-03-03

Who can join

Age: 4 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age equal to or greater than 4 years (patient must be able to void on request).
• Have good health.

You may not qualify if…

• Any prior history of renal disease, or hypertension
• ALL subjects (controls and affected patients) will be asked to discontinue any diuretics, calcium supplements, H2 blockers, proton pump inhibitors or gastrointestinal motility agents for approximately one week prior to initiation of the study.
• Subjects with GFR < 50 cc/min will be excluded.

Where it is running

• Mayo Clinic Rochester — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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