Optimal Heparin Dosing Regimens for Cardiopulmonary Bypass

Completed · Phase 3

Conditions studied: Postoperative Hemorrhage

In brief

Study has been completed and is in the data analysis and manuscript writing phase of the project.

Key facts

Study ID

NCT00587444

Run by

Mayo Clinic

People needed

270

Starts

2001-06-01

Expected to finish

2007-10-01

Last updated by the study team

2009-10-15

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult male and non-pregnant female patients scheduled for elective cardiac surgery requiring CPB will be eligible for enrollment.

You may not qualify if…

• Age less than 18 or greater than 90 years; emergency surgery
• Circulatory arrest
• Combined non-cardiac procedures such as carotid endarterectomy
• Congenital heart repair
• Off-CPB coronary artery bypass grafting (CABG)
• Clotting disorder
• Fibrinolytic agents (e.g. streptokinase), severe hepatic disease
• Aprotinin use
• Cooling < 28 degrees C during CPB
• Dialysis dependent renal failure; and
• Platelet receptor GP3a/2b antagonists medication received within 48 hours of surgery. Patients that are not receiving tranexamic acid (TA) intraoperatively will be excluded.

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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