L-arginine for Prevention of Kidney Damage in Liver Transplant Recipients
Completed · Not applicable · Has a placebo group
Conditions studied: Liver Transplant Recipients
In brief
Chronic renal insufficiency is a common and important health problem that causes morbidity and mortality among patients who have undergone liver transplantation. It is mainly caused by drugs (calcineurin inhibitors) that are used to prevent or treat rejection and once established, there is no effective treatment. This research investigates whether L-arginine can reverse the effects of calcineurin inhibitors on the kidneys and thus prevent renal insufficiency in liver transplant recipients.
Key facts
- Study ID
- NCT00587418
- Run by
- Mayo Clinic
- People needed
- 24
- Starts
- 2008-11-01
- Expected to finish
- 2012-07-01
- Last updated by the study team
- 2012-09-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Informed written consent
- Ages 18+ at the time of entry into the study
- Recipient of primary liver transplantation from a deceased or live donor
- Stable with satisfactory allograft function
- Total bilirubin < 2.5 mg/dl and
- Aminotransferase < x 3 upper limit of normal (e.g., ALT<120 IU/mL)
- Serum creatinine < 2.5 mg/dl without dialysis
- Maintenance immunosuppression including tacrolimus or cyclosporine
- Stable hemodynamic function
- Systolic blood pressure > 100 mmHg
- Resting pulse rate < 100
You may not qualify if…
- Recipient of combined liver-kidney transplantation
- Prior organ transplantation (i.e., exposure to calcineurin inhibitors)
- Established primary renal disease with active urinary sediments
- On-going renal replacement therapy
- Pulmonary hypertension (e.g., portopulmonary hypertension)
- Iodine allergy
- Other systemic illness (e.g., infection) that require hospitalization care beyond 2 weeks after LTx
Where it is running
- Mayo Clinic — Rochester, Minnesota, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.