Differences in Epicardial Plaque and Microvascular Function in Women With an Acute Myocardial Infarction
Completed · Not applicable
Conditions studied: Myocardial Infarction
In brief
The broad objective is to advance our understanding of both in vivo anatomical and functional changes that are present in the coronary arteries in women who have an acute coronary syndrome. Specific focus will be placed on the age of the women as there may be distinct differences in younger women (\< 50 years) given the marked increase in mortality in this population.
Key facts
- Study ID
- NCT00587002
- Run by
- Mayo Clinic
- People needed
- 65
- Starts
- 2007-03-01
- Expected to finish
- 2010-12-01
- Last updated by the study team
- 2011-04-15
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age of 18 years or older
- Acute coronary syndrome defined as at least two of the following:
- A) an elevated cardiac biomarker (troponin or CK-MB), B) new or dynamic ECG changes in at least 2 contiguous standard electrocardiographic leads of ST depression > 1 mm or ST elevation of >1 mm or T-wave inversions, C) chest pain or discomfort of at least 15 minutes duration, D) a new wall motion abnormality by echocardiography
- Patient who is undergoing coronary angiography
- Physician planning to perform IVUS for treatment of the infarct-related vessel
You may not qualify if…
- Creatinine > 2.0 mg/dL (most recent)
- Hemodynamically unstable patients (systolic blood pressure < 90 mmHg or heart rate > 110 beats/ minute or presence of an intra-aortic balloon pump)
- Coronary revascularization (percutaneously or surgically) within 6 months
- The use of chronic immunosuppressive agents
- No target lesion was found at the time of cardiac catheterization that will be percutaneously intervened upon (the patient must undergo percutaneous coronary intervention)
- Inability to give informed consent
- Pregnant or lactating women
- Prisoners
Where it is running
- Mayo Clinic — Rochester, Minnesota, United States
Full record on ClinicalTrials.gov
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