Heart Failure and a Preserved Ejection Fraction

Completed

Conditions studied: Heart Failure

In brief

This will be a cross sectional study comparing patients with HFpEF and age-matched, non-HF controls recruited from the community. This design will allow for determination of biologically relevant differences in baseline ventricular and vascular function, and importantly, differences in the ability to augment ventricular and vascular function dynamically during exercise stress, when symptoms of HF typically are first noted. The endpoint of exercise-reserve function is novel and has been little examined in the existing HFpEF literature.

Key facts

Study ID

NCT00586833

Run by

Mayo Clinic

People needed

51

Starts

2007-04-01

Expected to finish

2009-06-01

Last updated by the study team

2010-10-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Consultation by a cardiologist for HF in the past 1 year
• (HF rigorously defined by the modified Framingham criteria9),
• able to exercise on a treadmill

You may not qualify if…

• decompensated HF; significant valvular disease; infiltrative, restrictive, or hypertrophic cardiomyopathy; cor pulmonale or significant pulmonary limitation; unstable coronary disease; atrial fibrillation; pregnancy; inability to exercise or suspend vasoactive medicines for at least 24 hours

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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