Cardiac Sympathetic Activity in Patients With the Apical Ballooning Syndrome

Completed · Not applicable

Conditions studied: Apical Ballooning Syndrome

In brief

Our hypothesis is that altered cardiac sympathetic activity is present and may contribute to the myocardial stunning observed in the apical ballooning syndrome. Aim: Assess the extent and reversibility of cardiac adrenergic neuronal dysfunction using carbon-11 hydroxyephedrine (C-11 HED), a positron emission tomography (PET) tracer, in patients with the apical ballooning syndrome.

Key facts

Study ID

NCT00586183

Run by

Mayo Clinic

People needed

1

Starts

2006-03-01

Expected to finish

2006-12-01

Last updated by the study team

2008-01-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Transient akinesis or dyskinesis of the left ventricular apical and mid-ventricular segments with regional wall-motion abnormalities extending beyond a single epicardial vascular distribution.
• Absence of obstructive coronary disease or angiographic evidence of acute plaque rupture.
• New electrocardiographic abnormalities (either ST-segment elevation or T-wave inversion.
• Absence of recent significant head trauma, intracranial bleeding, pheochromocytoma, myocarditis, hypertrophic cardiomyopathy.

You may not qualify if…

• Hemodynamically unstable patients (requiring pressor support) will be excluded.
• Breastfeeding women.
• Pregnant women (urine pregnancy test required within 48 hours prior to each set of PET scans.

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.