Age and Endothelial Progenitor Cell Mobilization

Completed

Conditions studied: Coronary Artery Disease

In brief

It is hypothesized that aging is associated with reduced vascular injury-induced endothelial progenitor cell activity, resulting in impaired vascular repair and increased vascular disease. Patients with stable coronary artery disease will be enrolled in this observational study and will undergo either angiography alone or angiography and angioplasty. Participants will be followed for 5 years.

Key facts

Study ID

NCT00585949

Run by

Emory University

People needed

123

Starts

2006-07-01

Expected to finish

2008-10-09

Last updated by the study team

2020-03-05

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients having stable coronary artery disease and undergoing either angiography or angioplasty

You may not qualify if…

• Unstable coronary artery disease associated with either EKG changes or elevation of cardiac enzymes
• Coronary intervention in the past 3 months
• Renal insufficiency
• Malignancy within the past 5 years except non-melanomatous skin cancers
• Recent infection within the past 3 months requiring antibiotic treatment
• Recent surgery requiring anesthesia within the past 3 months
• Having inflammatory disease
• Chemotherapy, radiation therapy or bone marrow stimulants at any time in the past
• Menstruating women
• Recent changes in statin, angiotensin-converting enzyme (ACE) inhibitors, or angiotensin receptor blocker doses

Where it is running

• Atlanta VA Medical Center — Atlanta, Georgia, United States
• Emory University Hospital — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

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